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KMID : 0360219720130030015
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Journal of the Korean Ophthalmological Society
1972 Volume.13 No. 3 p.15 ~ p.20
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Experimental Degeneration of the Rabbits Retina by Sodium Glutamate
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Abstract
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Intravitreal and .intraperitoneal administrations- of sodin:n , L glutamate induced the retinal degenerations in adult rabbits.
Electroretiongram was completely extinguished by the intravitreal injection of glutamate (50mg in:O.Imi) followed by slight recovery. The retina showed marked thinning with almost diffuser degeneration in all retinal layers.
Intraperitoneal injection of a sigle large dose of glutamate(8g/Kg) produced moderate reduction in the amplitudes of a-and b-waves with degenerative changes in the retina, mainly involving theinner layers and the periphery of the fundus, parallel to the ERG changes.
Administrations of small doses (2. 5g/Kg and 5. 0 g,./Kg) for 7 days induced moderate reduction in the a-and b-waves with slight histological changes, especially marked in the inner layers of the retina.
Possible mechanisms of the toxic effects of glutamate were discussed.
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